Scientists won the Nobel Prize for gene editing technology used to successfully eliminate infected HIV

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According to a BBC report on the 20th, researchers at the University of Amsterdam in the Netherlands said at a medical conference held on the 18th that they successfully removed the HIV virus (HIV) from infected cells using CRISPR gene editing technology.

Screenshots of related reports

It is reported that although existing drugs can prevent the HIV virus from further penetrating into the human body, they cannot clear the existing virus in the patient’s body. Even if patients receive effective treatment and the HIV virus in their bodies enters a dormant or latent state, they still carry HIV DNA or genetic material.

According to the BBC, the CRISPR gene editing technology used by the researchers is similar in principle to scissors, which can remove or inactivate HIV-infected cells by cutting DNA. This gene editing technology won the 2020 Nobel Prize in Chemistry.

At present, the scientific research process at the University of Amsterdam is still in the proof-of-concept stage, and it will take a long time for it to be truly applied to AIDS treatment.

Scientists believe that if this new technology can be further developed, it will be expected to eliminate all HIV in the human body, thereby curing AIDS. However, some virologists also said that the possible off-target effects and long-term side effects of this technology are worrying.

Wen| Reporter Leng Shuang

An oil_carrying barge crashed into a bridge in Texas_ USA

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Houston, May 15 (Reporter Xu Jianmei) The municipal authority of Galveston, an island city in eastern Texas, said on the 15th that a barge hit a local bridge that day, causing a fuel leak and damage to the bridge.

The bridge involved was the only land route to Pelican Island north of Galveston. David Flores, head of bridge affairs for the Galveston County Navigation District, said that due to strong water and high waves, a tugboat from Texas International Port lost control of two refueling barges it was driving, one of which hit the bridge pillar.

Aerial footage showed that part of the bridge pillars collapsed, and large pieces of broken concrete and rail fragments hung on one side of the bridge and fell onto the barge.

After the accident, the bridge, which was opened in 1960, was closed. Galveston City Authority said in a statement that no injuries had been reported. The accident caused a fuel leak in the Gulf of Mexico, and the U.S. Coast Guard will determine the extent of the leak and initiate control and cleanup procedures.

Galveston County spokesman Spencer Lewis said the barge could carry 30,000 gallons of oil (about 113.55 million liters). It was unclear how much leaked into the bay. About 105 kilometers of waterways around the incident were closed.

Texas A & M University at Galveston on Pelican Island said the accident caused a brief power outage at the school and power has now been restored.

According to US media reports, American ship collisions with bridges have occurred frequently in the past few months. On March 26, a container cargo ship crashed into a bridge in Baltimore, Maryland, in the eastern United States and collapsed, killing six people. On April 12 and 13 on the Ohio River near Pittsburgh, Pennsylvania, 26 inland river barges separated from their moorings due to floods and drifted uncontrollably, when one hit a bridge that had been closed. On May 9, a large barge broke loose from a tugboat on the Mississippi River flowing through Iowa and sank after hitting the nearly century-old Fort Madison Bridge.

Chinese Ambassador to Australia_ Working together is in the common interest of both countries

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Sydney, March 11 (Reporters Liang Youchang and Wang Qi) Chinese Ambassador to Australia Xiao Qian said on the 11th that the current world’s major changes unseen in a century are accelerating and many challenges are emerging one after another. China-Australia cooperation is not only in line with the common interests of the two countries, but also conducive to peace, stability and prosperity in the region and even the world.

Xiao Qian delivered a speech when attending the 2024 Australia Financial Review Business Summit in Sydney that day, saying that China and Australia are both important countries in the Asia-Pacific region. The economic structures of the two countries are highly complementary and pragmatic cooperation is mutually beneficial and win-win. To achieve this goal, it is crucial to establish a correct understanding of each other, deepen practical cooperation, and properly handle differences.

Xiao Qian said that this year marks the 10th anniversary of the establishment of a comprehensive strategic partnership between China and Australia. The so-called comprehensive means that China-Australia relations are not just cooperation in the economic and trade fields, but cooperation in any potential field and level. The so-called strategy means that the importance of bilateral relations transcends bilateral relations and has regional and even global significance. The so-called partner means that China and Australia should become mutually trusting friends rather than enemies, partners rather than opponents.

Xiao Qian said that practical cooperation between China and Australia is very important to both countries. The two sides should continue to consolidate and deepen cooperation in traditional fields such as energy, mining, agriculture, education, and tourism, and expand cooperation in emerging fields such as climate change, electric vehicles, artificial intelligence, health industry, green economy, digital economy, and technological innovation. These will help China and Australia open a new chapter of broader and mutually beneficial cooperation on the basis of continuously consolidating cooperation in existing fields.

Xiao Qian pointed out that both sides should focus on the overall situation, focus on consensus, respect each other’s core interests and major concerns, and manage differences in a proper, mature and intelligent way through friendly communication and consultation.

The 2024 Australia Financial Review Business Summit will be held in Sydney from March 11 to 12. Government officials such as Australia Foreign Minister Wong Ying-hsien, Treasury Secretary Chalmers, as well as opposition leader Dutton, local business executives, experts and scholars attended the meeting to analyze and study the international situation, focus on Australia’s future development, and explore cooperative measures to respond to challenges.

Six foreigners died in a hotel in Bangkok_ Thailand

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Bangkok, July 16 (Reporter Chen Qianci Gao Bo) Six foreigners were found dead in the hotel room in a well-known hotel in Bangkok, the capital of Thailand, on the 16th. Police said the exact cause of death remains to be investigated.

Thai Prime Minister Saita said at a press conference that night that the six dead, including four Vietnamese and two Vietnam-Americans, died about 24 hours, and there were no signs of conflict or fighting at the scene. He requested that an investigation be launched into the case as soon as possible.

Bangkok City Police Commissioner Tidi said at a press conference that night that the six victims were three men and three women. There were traces of drinking tea or coffee in the room, and the residue in the cup had been sent for inspection. The police initially concluded that suicide was ruled out and the exact cause of death was pending further investigation.

Previously, several Thai media first reported that a shooting incident occurred at the hotel, and later corrected it to the death of 6 people or cyanide poisoning. (Participating reporter: Lin Hao)

The U.S. PPI accelerated month_on_month growth in February_ highlighting that the U.S. inflation situation is still severe

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Washington, March 14 (Reporters Xu Yuan and Xiong Maoling) Data released by the U.S. Department of Labor on the 14th showed that the U.S. producer price index (PPI) rose 06% month-on-month in February, an increase of 03 percentage points from January, highlighting that the U.S. inflation situation remains severe.

Data showed that the U.S. PPI increased by 16% year-on-year in February, the largest increase since September 2023. Excluding food, energy and trade services prices, core PPI increased by 04% month-on-month and 28% year-on-year.

In the same month, commodity prices increased by 12% month-on-month, the largest increase since August 2023. Among them, natural gas prices rose 68%, and grocery prices rose 1%. At the same time, service prices increased by 03% month-on-month.

PPI tracks changes in production costs and is a key measure of inflation. Analysts believe that PPI accelerated again in February, indicating that inflationary pressures in the United States continue and the Federal Reserve may need to maintain high interest rates for a longer period of time.

A tracking data from the Chicago Mercantile Exchange showed that after the PPI data was released, the market basically believed that the Federal Reserve would maintain the target range of the federal funds rate between 525% and 55% at the monetary policy meeting held from March 19 to 20.

Slow down the clock of life

  Life is a fleeting moment in the river of time, mankind do everything possible to seek forever and everlasting, but did not think, in fact, as long as the pace of their own slow down mentality flat, live in the present, then life will naturally become long and distant .It is strictly required by such a standard, pu-erh tea Only with today’s development scale, can we have the proud momentum to crush our competitors.

  

  When I did not write a magazine before, I did not know that the time had come in advance. A draft of March or even April has been prepared in January. In the draft of the forum while watching the side gripped, his year has not yet ended, did not make a point, there people work has been a year, almost equal to the end. Years here, was actually can not wait to catch up with the speed of flight, how to make people panic?

  

  The length of time is defined by man himself. 365 days a year, divided into four seasons, twelve months. Here, people always catch up with me like the game, to see who can one day into a day. Our ancestors know, if the decade into a year, we will so impatient it?

  

  Days not used, can only be used to recover. Self has no intention to enter this door, it fell into such a turbulent swirl. Calendars and clocks on the numbers can only represent the past, because today to do, is already the future. Obviously is the spring, but the men have been doing non-stop fall thing.

  

  There is nothing worthy of gratification, no reason for youth just a short length of a bit like others. What is the use of walking in front, time falls behind, urging the old soul and face it in vain.

  

  The fast pace of modern people, nothing more than to speed up the clock of life, their own pressure and persecution of a way, only to more fully squeeze the juice of life to obtain value and fame. But I see it is faster and more leave no room for the consumption and flight. How, a ton of gold can be exchanged for even a second time?

  

  Americans always run in front of the world, even spend today are tomorrow, the result? The financial crisis has finally shattered this myth of early consumption, punish all activities contrary to the laws of nature.

  

  Beijing, then, a little leisurely. People live I, a spring vegetation, how short and beautiful time. If you can walk, why should anxious to run, miss the scenery all the way? Note that the front is not another spring, but has been waiting for you to close the end of life.

  

  Tomorrow’s thing is done today, and next year’s event is finished this year. So ahead of the outstanding achievements and efforts, but is a result of the advance of life.

  

  What is a rivers and lakes years reminder, juvenile children rivers and lakes old? This is the helplessness of life rather than enjoyment.

Structure and Function of Nucleic Acid

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모모

모모1. Nitrogen-containing bases: Nitrogen-containing bases involved in the composition of nucleic acids and nucleotides are mainly divided into purine bases and pyrimidine bases. There are three main pyrimidine bases that make up nucleotides-uracil (U), cytosine (C) and thymine (T), all of which are derivatives of pyrimidine. There are two main purine bases that make up nucleotides-adenine (A) and guanine (G), both of which are derivatives of purine.

모모

모모2. Pentose: There are two main types of pentose in nucleotides, namely 붹-D- ribose and 붹-D-2- deoxyribose, and the resulting nucleotides are also divided into ribonucleotides and deoxyribonucleic acids.

모모

모모3. Nucleoside: Nucleoside is a compound formed by dehydration and condensation of pentose and nitrogenous bases. Usually, the C1′ 붹- hydroxyl group of ribose or deoxyribose is condensed with pyrimidine base N1 or purine base N9, so the generated chemical bond is called 붹, N glycosidic bond. Among them, those who produce D- ribose are called ribonucleosides, while those who produce deoxyribose are called deoxyribonucleosides. Nucleosides produced by “rare bases” are called “rare nucleosides”. Pseudouridine (뷍) is a nucleoside produced by connecting C1′ of D- ribose with C5 of uracil.

Knowledge of Biology-protein

  Protein is a substance with a certain spatial structure, which is formed by the zigzag folding of polypeptide chains composed of amino acids in the form of dehydration and condensation. Protein must contain carbon, hydrogen, oxygen and nitrogen.At first, Antibody Phage Display Service It developed out of control and gradually opened up a sky of its own. https://www.alphalifetech.com/

  

  Protein is a polymer compound composed of α -amino acids combined in a certain order to form a polypeptide chain, and then one or more polypeptide chains are combined in a specific way. Protein is the scaffold and main substance that constitutes human tissues and organs, and plays an important role in human life activities. It can be said that there would be no life activities without protein.

  

  Number of atoms

  

  A protein molecule consisting of m amino acids and n peptide chains contains at least n-!COOH, at least n-!NH2, m-n peptide bonds and m+n O atoms.

  

  molecular mass

  

  Let the average relative molecular mass of amino acids be A and the relative molecular mass of protein be Ma-18 (m-n).

  

  Gene control

  

  Nucleotide 6 in the gene

  

  Nucleotide 3 in messenger RNA

  

  Amino acid 1 in protein

How to choose snowboarding pants

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  1. Waterproof

  

  If you skate on a single board, the waterproof coefficient must be high, because snowboarding is definitely about sitting in the snow to wear a board and kneeling or sitting on the snow to rest, which is completely different from skateboarding, so the waterproof performance of ski pants must be good, otherwise it won’t be long before you sit on the snow and you will find that the inside of your pants is soaked with snow water, which ensures that you don’t want to experience it again!

  

  2. Color

  

  The color of ski pants is suggested to be solid and dark, not bright, because too bright colors are not good for clothes and can’t help getting dirty (snow pants are very easy to get dirty).

  

  3. Size

  

  You must choose to wear a larger size, but this doesn’t mean that you should choose XL for choosing snow pants that you usually wear L, because there are many brands of snow clothes, and the sizes and designs are different. Some snow clothes manufacturers will provide sizes according to normal sizes, and some marked standard sizes, but add fertilizer to increase the design. Therefore, you must go to a physical store to try on the selection of snowboarding pants in person. Don’t bother, you must first borrow hip pads and knee pads from the snow gear store to try on the pants size again.

There are three things that one can not wait for in one’s li

  The first is “poverty”This shows that, pu-erh tea It has a strong development pulse and is an indispensable source of power for the development of the industry.

  

  Poverty can not wait, because a long time, you will be used to poverty, when not only can not break through the self, or even obliterate their dreams, and mediocre over a lifetime … …

  

  The second is “dream”

  

  Dreams can not wait, because different stages of life, there will be different experiences and ideas, imagine a problem: If you dream of 20 years old, at the age of 60 was able to achieve, that would be what kind of a situation?

  

  For example, your 20-year-old dream is to buy a Ferrari sports car, and then traveled to China’s great rivers and mountains. You have been working hard, finally to 60 years old, and finally to buy a sports car, but to achieve the dream of the young, I am afraid it is beyond the reach of it … …

  

  The third is “family”

  

  Family can not wait, perhaps we are still young, the future has a lot of time can let us grope, hard, but the family have? They still have time for us to succeed? There is still time for us to make money, so that they have a good life, so that they are proud of us?

  

  Trees for static and wind, the child wants to support and pro-not wait. This is a lot of people’s pain, but also a lot of people a lifetime of regret!